Risk Management

Laser Surgery for ROP

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Laser Surgery to treat ROP

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Articles on neurodevelopment after Avastin (bevacizumab) injection

OMIC and our ROP Task Force want to let you know of some studies on the effect of Avastin on the infant’s neurodevelopment. We have revised our ROP consent forms to address this research.

Pediatrics published a report[1] showing that the odds of severe neurodevelopmental disabilities was 3.1 times higher in infants treated with Avastin than those treated with laser. Another article[2] showed increased odds only in infants treated with both Avastin and laser.

Research is ongoing to determine if Avastin and other anti-VEGF drugs are safe. In the meantime, we all have to explain what we do know about these drugs to parents whose infants need treatment for ROP.


Please contact our confidential Risk Management Hotline if you need help developing or revising your protocols. You may email us at riskmanagement@omic.com or call 800-562-6642, option 4.



[1] Warren J, Luu TM, Superstein R, et al. Neurodevelopmental Outcomes Following Bevacizumab Injections for Retinopathy of Prematurity. Pediatrics. 2016; 137 (4): e20153218. http://pediatrics.aappublications.org/content/early/2016/03/16/peds.2015-3218

2 Lien R, Yu M-H, Hsu K-H, Liao P-J, Chen Y-P, Lai C-C, et al. (2016) Neurodevelopmental Outcomes in Infants with Retinopathy of Prematurity and Bevacizumab Treatment. PLoS ONE 11(1): e0148019. doi:10.1371/journal.pone.0148019. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148019

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